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Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer

30 Oct 2018

Abstract excerpt

PURPOSE: Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing has traditionally been performed in patients with colorectal (CRC) and endometrial cancer (EC) to screen for Lynch syndrome (LS)-associated cancer predisposition. The recent success of immunotherapy in high-frequency MSI (MSI-H) and/or MMR-D tumors now supports testing for MSI in all advanced solid tumors. The extent to...

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PMID: 30376427
DOI: 10.1200/jco.18.00283

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