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Article

Microsatellite instability: A 2024 update.

Cancer science - 1 Jun 2024

Yamamoto Hiroyuki, Watanabe Yoshiyuki, Arai Hiroyuki, Umemoto Kumiko, Tateishi Keisuke, Sunakawa Yu

Abstract excerpt

Deficient mismatch repair (dMMR) results in microsatellite instability (MSI), a pronounced mutator phenotype. High-frequency MSI (MSI-H)/dMMR is gaining increasing interest as a biomarker for advanced cancer patients to determine their eligibility for immune checkpoint inhibitors (ICIs). Various methods based on next-generation sequencing (NGS) have been developed to assess the MSI status. Comprehensive genomic...

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Identifiers

PMID: 38528657
DOI: 10.1111/cas.16160
PMCID: PMC11145116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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