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Article

Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours.

Acta neuropathologica communications - 6 Jun 2017

Haque Farhana, Varlet Pascale, Puntonet Julien, Storer Lisa, Bountali Aikaterini, Rahman Ruman, Grill Jacques, Carcaboso Angel M, Jones Chris, Layfield Robert, Grundy Richard G

Abstract excerpt

Missense somatic mutations affecting histone H3.1 and H3.3 proteins are now accepted as the hallmark of paediatric diffuse intrinsic pontine gliomas (DIPG), non-brain stem paediatric high grade gliomas (pHGG) as well as a subset of adult glioblastoma multiforme (GBM). Different mutations give rise to one of three amino acid substitutions at two critical positions within the histone tails, K27M, G34R/V. Several...

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Identifiers

PMID: 28587626
DOI: 10.1186/s40478-017-0449-1
PMCID: PMC5461722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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