Article
A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.
Acta neuropathologica - 1 Nov 2014
Venneti Sriram, Santi Mariarita, Felicella Michelle Madden, Yarilin Dmitry, Phillips Joanna J, Sullivan Lisa M, Martinez Daniel, Perry Arie, Lewis Peter W, Thompson Craig B, Judkins Alexander R
Abstract excerpt
Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM and ~80 % of diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. H3F3A K27M mutations lead to global reduction in H3K27me3. Our goal was to develop biomarkers for the histopathologic detection of these tumors. Therefore, we...
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