Article

A conditional histone H3.3 mutation in mice orthologous to a driver of paediatric diffuse instrinsic pontine glioma

2022-11-26

Abstract excerpt

<h4>ABSTRACT</h4> Most paediatric diffuse intrinsic pontine gliomas carry a lysine- to methionine-27 (K27M) mutation in the histone variant H3.3 encoded by the ‘H3.3 histone A’ ( H3F3A ) gene. To establish a pre-clinical model of the disease we made a Cre/ loxP conditional H3.3K27M mutation at the orthologous H3f3a locus in mice. Importantly, expression of the mutant transcript is under endogenous H3f3a regul...

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Literature Corpus work: 8fb4fe3a-37c3-5e76-881b-1788cbfc879b
DOI: 10.1101/2022.11.25.518018

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