Article
EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production.
Zoological research - 18 May 2017
Zheng Wang-Shan, He Yao-Xi, Cui Chao-Ying, Ouzhu Luobu, Deji Quzong, Peng Yi, Bai Cai-Juan, Duoji Zhuoma, Gongga Lanzi, Bian Ba, Baima Kangzhuo, Pan Yong-Yue, Qu la, Kang Min, Ciren Yangji, Baima Yangji, Guo Wei, Yang la, Zhang Hui, Zhang Xiao-Ming, Guo Yong-Bo, Xu Shu-Hua, Chen Hua, Zhao Sheng-Guo, Cai Yuan, Liu Shi-Ming, Wu Tian-Yi, Qi Xue-Bin, Su Bing
Abstract excerpt
The genetic adaptation of Tibetans to high altitude hypoxia likely involves a group of genes in the hypoxic pathway, as suggested by earlier studies. To test the adaptive role of the previously reported candidate gene EP300 (histone acetyltransferase p300), we conducted resequencing of a 108.9 kb gene region of EP300 in 80 unrelated Tibetans. The allele-frequency and haplotype-based neutrality tests detected...
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