Article
Sequencing of 50 human exomes reveals adaptation to high altitude.
Science (New York, N.Y.) - 2 Jul 2010
Yi Xin, Liang Yu, Huerta-Sanchez Emilia, Jin Xin, Cuo Zha Xi Ping, Pool John E, Xu Xun, Jiang Hui, Vinckenbosch Nicolas, Korneliussen Thorfinn Sand, Zheng Hancheng, Liu Tao, He Weiming, Li Kui, Luo Ruibang, Nie Xifang, Wu Honglong, Zhao Meiru, Cao Hongzhi, Zou Jing, Shan Ying, Li Shuzheng, Yang Qi, Asan, Ni Peixiang, Tian Geng, Xu Junming, Liu Xiao, Jiang Tao, Wu Renhua, Zhou Guangyu, Tang Meifang, Qin Junjie, Wang Tong, Feng Shuijian, Li Guohong, Huasang, Luosang Jiangbai, Wang Wei, Chen Fang, Wang Yading, Zheng Xiaoguang, Li Zhuo, Bianba Zhuoma, Yang Ge, Wang Xinping, Tang Shuhui, Gao Guoyi, Chen Yong, Luo Zhen, Gusang Lamu, Cao Zheng, Zhang Qinghui, Ouyang Weihan, Ren Xiaoli, Liang Huiqing, Zheng Huisong, Huang Yebo, Li Jingxiang, Bolund Lars, Kristiansen Karsten, Li Yingrui, Zhang Yong, Zhang Xiuqing, Li Ruiqiang, Li Songgang, Yang Huanming, Nielsen Rasmus, Wang Jun, Wang Jian
Abstract excerpt
Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were identified. The strongest signal of natural selection came from...
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