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Article

Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among eurasian human populations.

Molecular biology and evolution - 1 Nov 2012

Ji Lin-Dan, Qiu Yu-Qing, Xu Jin, Irwin David M, Tam Siu-Cheung, Tang Nelson L S, Zhang Ya-ping

Abstract excerpt

Research into the mechanisms of human adaptation to the hypoxic environment of high altitude is of great interest to the fields of human physiology and clinical medicine. Recently, the gene EGLN1, from the hypoxia-inducible factor (HIF) pathway, was identified as being involved in the hypoxic adaptation of highland Andeans and Tibetans. Both highland Andeans and Tibetans have adapted to an extremely hypoxic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22628534
DOI: 10.1093/molbev/mss144

Genes

EGLN1
OPRM1
DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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