Article
HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans.
Human mutation - 1 Feb 2016
Yang Deying, Peng Yi, Ouzhuluobu, Bianbazhuoma, Cui Chaoying, Bianba, Wang Liangbang, Xiang Kun, He Yaoxi, Zhang Hui, Zhang Xiaoming, Liu Jiewei, Shi Hong, Pan Yongyue, Duojizhuoma, Dejiquzong, Cirenyangji, Baimakangzhuo, Gonggalanzi, Liu Shimin, Gengdeng, Wu Tianyi, Chen Hua, Qi Xuebin, Su Bing
Abstract excerpt
Tibetans are well adapted to high-altitude environments. Among the adaptive traits in Tibetans, the relatively low hemoglobin level is considered a blunted erythropoietic response to hypoxic challenge. Previously, EPAS1 and EGLN1, the major upstream regulators in the hypoxic pathway, were reportedly involved in the hemoglobin regulation in Tibetans. In this study, we report a downstream gene (HMOX2) involved in...
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