Article

Tibetan near-complete pangenome reveals complex variants underlying high-altitude adaptation

2025-12-21

Abstract excerpt

Genomic diversity in indigenous populations offers critical insights into human evolution and population-specific adaptation. Here, we generated 70 near-complete, fully phased genome assemblies from 35 high-altitude Tibetan trios and identified 4.55 million small variants and 63,031 structural variants (SVs) absent from the current global pangenome reference. Comparative analyses with a 595 globally diverse long-r...

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Literature Corpus work: db71934d-b29d-571d-b7f8-81a97af7a917
DOI: 10.64898/2025.12.16.694547

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