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Article

Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 2017

Montero-Conde Cristina, Leandro-Garcia Luis J, Chen Xu, Oler Gisele, Ruiz-Llorente Sergio, Ryder Mabel, Landa Iñigo, Sanchez-Vega Francisco, La Konnor, Ghossein Ronald A, Bajorin Dean F, Knauf Jeffrey A, Riordan Jesse D, Dupuy Adam J, Fagin James A

Abstract excerpt

Oncogenic RAS mutations are present in 15-30% of thyroid carcinomas. Endogenous expression of mutant Ras is insufficient to initiate thyroid tumorigenesis in murine models, indicating that additional genetic alterations are required. We used Sleeping Beauty (SB) transposon mutagenesis to identify events that cooperate with HrasG12V in thyroid tumor development. Random genomic integration of SB transposons...

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Source

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Identifiers

PMID: 28584132
DOI: 10.1073/pnas.1702723114
PMCID: PMC5488945

Genes

ATXN7
IMPACT
NF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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