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Article

AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells.

Human gene therapy - 1 Sept 2017

Sanchez Anamaria C, Li Chengwen, Andrews Barbara, Asenjo Juan A, Samulski R Jude

Abstract excerpt

Most ethanol is broken down in the liver in two steps by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) enzymes, which metabolize down ethanol into acetaldehyde and then acetate. Some individuals from the Asian population who carry a mutation in the aldehyde dehydrogenase gene (ALDH2*2) cannot metabolize acetaldehyde as efficiently, producing strong effects, including facial flushing, dizziness,...

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Share to Acetaldehyde
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Aldehyde Dehydrogenase, Mitochondrial

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Source

Open in PubMed Open full text

Identifiers

PMID: 28578603
DOI: 10.1089/hum.2017.043
PMCID: PMC5582589

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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