Article
Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration.
Alcoholism, clinical and experimental research - 1 Jan 2011
Matsumoto Michinaga, Cyganek Izabela, Sanghani Paresh C, Cho Won Kyoo, Liangpunsakul Suthat, Crabb David W
Abstract excerpt
BACKGROUND: Human class I alcohol dehydrogenase 2 isoenzymes (encoded by the ADH1B locus) have large differences in kinetic properties; however, individuals inheriting the alleles for the different isoenzymes exhibit only small differences in alcohol elimination rates. This suggests that other cellular factors must regulate the activity of the isoenzymes. METHODS: The activity of the isoenzymes expressed from...
Topics
- Acetaldehyde
- Alcohol Dehydrogenase
- Aldehyde Dehydrogenase
- Alleles
- Animals
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Central Nervous System Depressants
- Ethanol
- HeLa Cells
- Hepatocytes
- Humans
- Isoenzymes