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Article

Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration.

Alcoholism, clinical and experimental research - 1 Jan 2011

Matsumoto Michinaga, Cyganek Izabela, Sanghani Paresh C, Cho Won Kyoo, Liangpunsakul Suthat, Crabb David W

Abstract excerpt

BACKGROUND: Human class I alcohol dehydrogenase 2 isoenzymes (encoded by the ADH1B locus) have large differences in kinetic properties; however, individuals inheriting the alleles for the different isoenzymes exhibit only small differences in alcohol elimination rates. This suggests that other cellular factors must regulate the activity of the isoenzymes. METHODS: The activity of the isoenzymes expressed from...

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Source

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Identifiers

PMID: 21166830
DOI: 10.1111/j.1530-0277.2010.01319.x
PMCID: PMC3059091

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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