Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research.

Alcohol (Fayetteville, N.Y.) - 1 Mar 2009

Cortínez Gabriel, Sapag Amalia, Israel Yedy

Abstract excerpt

Liver alcohol dehydrogenase oxidizes ethanol to acetaldehyde, which is further oxidized to acetate by aldehyde dehydrogenase-2 (ALDH2*1). Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde levels after ethanol consumption, which leads to dysphoric effects, such a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Aldehyde Dehydrogenase
Share to Aldehyde Dehydrogenase, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Phenotype

Share to RNA Interference

Share to RNA, Small Interfering

Source

Identifiers

PMID: 19251111
DOI: 10.1016/j.alcohol.2008.12.007

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19251111-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research.PMID 19251111Read ↗

AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells.Semantic proximity Read ↗

Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol.Semantic proximity Read ↗

A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines.Semantic proximity Read ↗

Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA.Semantic proximity Read ↗

Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion.Semantic proximity Read ↗

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.Semantic proximity Read ↗

Global Changes in Gene Expression and Splicing in Alcoholic Liver DiseaseSemantic proximity Read ↗

A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant.Semantic proximity Read ↗

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.Semantic proximity Read ↗

Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.Semantic proximity Read ↗

Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.Semantic proximity Read ↗

miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.