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Article

Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver disease

2020-08-25

Abstract excerpt

<h4>Background</h4> It is unknown whether liver sinusoidal endothelial cells (LSECs) metabolize alcohol. Chronic alcohol consumption decreases endothelial nitric oxide synthase (eNOS)-derived NO production typical of LSEC dysfunction. Heat shock protein 90 (Hsp90) interacts with eNOS to increase its activity. Cytochrome P450 2E1 (CYP2E1) is a key enzyme in alcohol metabolism and facilitates protein acetylation vi...

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Literature Corpus work
0aac6e8f-1630-524b-be36-b2d37633ef50
DOI
10.1101/2020.08.25.267096
Open publication

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Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver diseaseDOI 10.1101/2020.08.25.267096
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