Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA.

Alcoholism, clinical and experimental research - 1 Aug 2005

Karahanian Eduardo, Ocaranza Paula, Israel Yedy

Abstract excerpt

BACKGROUND: Individuals carrying the Glu487Lys coding mutation in the gene for mitochondrial aldehyde dehydrogenase (ALDH2) have a diminished capacity to metabolize acetaldehyde. This deficiency leads to increases in blood acetaldehyde levels when they consume ethanol, which results in an aversion to alcohol and in marked protection against alcoholism. In the present studies, we aimed to mimic the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaldehyde
Share to Adenoviridae
Share to Alcoholism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aldehyde Dehydrogenase

Share to Aldehyde Dehydrogenase, Mitochondrial

Share to Ethanol

Share to Liver Neoplasms, Experimental

Share to RNA, Antisense

Source

Identifiers

PMID: 16131845
DOI: 10.1097/01.alc.0000174909.91034.7c

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA.PMID 16131845Read ↗

AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells.Semantic proximity Read ↗

Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol.Semantic proximity Read ↗

Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion.Semantic proximity Read ↗

RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research.Semantic proximity Read ↗

The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells.Semantic proximity Read ↗

Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase.Semantic proximity Read ↗

Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration.Semantic proximity Read ↗

Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats.Semantic proximity Read ↗

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.Semantic proximity Read ↗

Mitochondrial ALDH2 deficiency as an oxidative stress.Semantic proximity Read ↗

Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.Semantic proximity Read ↗

A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.