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Article

Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.

International journal of molecular sciences - 12 Sept 2020

Hsu Lung-An, Tsai Feng-Chun, Yeh Yung-Hsin, Chang Chi-Jen, Kuo Chi-Tai, Chen Wei-Jan, Tsai Hsin-Yi, Chang Gwo-Jyh

Abstract excerpt

Aldehyde dehydrogenase 2 (ALDH2) is an enzyme that detoxifies reactive oxygen species (ROS)-generated aldehyde adducts such as 4-hydroxy-trans-2-nonenal (4-HNE). Previous meta-analyses have shown an increase in the risk of atrial fibrillation (AF) in patients with chronic alcohol consumption. ALDH2*2, a common dysfunctional polymorphism in the ALDH2 gene, has been linked to an increased risk of cancer and heart...

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Identifiers

PMID: 32932651
DOI: 10.3390/ijms21186678
PMCID: PMC7555032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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