Article
The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells.
The Journal of clinical investigation - 1 Nov 1995
Xiao Q, Weiner H, Johnston T, Crabb D W
Abstract excerpt
Individuals heterozygous or homozygous for the variant aldehyde dehydrogenase (ALDH2) allele (ALDH2*2), which encodes a protein differing only at residue 487 from the normal protein, have decreased ALDH2 activity in liver extracts and experience cutaneous flushing when they drink alcohol. The mechanisms by which this allele exerts its dominant effect is unknown. To study this effect, the human ALDH2*1 cDNA was...
Topics
- Aldehyde Dehydrogenase
- Alleles
- Base Sequence
- DNA, Complementary
- HeLa Cells
- Heterozygote
- Homozygote
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Transfection