Article
Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2017
Saito Kohta, Warrier Thulasi, Somersan-Karakaya Selin, Kaminski Lina, Mi Jianjie, Jiang Xiuju, Park Suna, Shigyo Kristi, Gold Ben, Roberts Julia, Weber Elaina, Jacobs William R, Nathan Carl F
Abstract excerpt
Mycobacterium tuberculosis (Mtb) encounters stresses during the pathogenesis and treatment of tuberculosis (TB) that can suppress replication of the bacteria and render them phenotypically tolerant to most available drugs. Where studied, the majority of Mtb in the sputum of most untreated subjects with active TB have been found to be nonreplicating by the criterion that they do not grow as colony-forming units...
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