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De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis from the Persistence Phase Cells Formed against Antituberculosis Drugs In Vitro.

Antimicrobial agents and chemotherapy - 1 Feb 2017

Sebastian Jees, Swaminath Sharmada, Nair Rashmi Ravindran, Jakkala Kishor, Pradhan Atul, Ajitkumar Parthasarathi

Abstract excerpt

Bacterial persisters are a subpopulation of cells that can tolerate lethal concentrations of antibiotics. However, the possibility of the emergence of genetically resistant mutants from antibiotic persister cell populations, upon continued exposure to lethal concentrations of antibiotics, remained unexplored. In the present study, we found that Mycobacterium tuberculosis cells exposed continuously to lethal...

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Identifiers

PMID: 27895008
DOI: 10.1128/AAC.01343-16
PMCID: PMC5278719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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