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Article

Assessing the propensity of TB clinical isolates to form viable but non-replicating subpopulations.

Scientific reports - 12 Nov 2024

Coetzee Julian L, Kriel Nastassja L, Loubser Johannes, Dippenaar Anzaan, Sampson Samantha L, Malherbe Stephanus T, Mouton Jacoba M

Abstract excerpt

Current tuberculosis (TB) treatment is typically effective against drug-susceptible Mycobacterium tuberculosis, but can fail due to acquired drug resistance or phenotypic resistance. M. tuberculosis persisters, a subpopulation of viable but non-replicating (VBNR) antibiotic-tolerant bacteria, are thought to contribute to poor TB treatment outcomes. In this exploratory study, we investigated treatment-naïve...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39532967
DOI: 10.1038/s41598-024-79389-w
PMCID: PMC11557868

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