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AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress.

Angewandte Chemie (International ed. in English) - 17 Jul 2017

Liu Yu, Fares Matthew, Dunham Noah P, Gao Zi, Miao Kun, Jiang Xueyuan, Bollinger Samuel S, Boal Amie K, Zhang Xin

Abstract excerpt

Drug-induced proteome stress that involves protein aggregation may cause adverse effects and undermine the safety profile of a drug. Safety of drugs is regularly evaluated using cytotoxicity assays that measure cell death. However, these assays provide limited insights into the presence of proteome stress in live cells. A fluorogenic protein sensor is reported to detect drug-induced proteome stress prior to cell...

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PMID: 28557281
DOI: 10.1002/anie.201702417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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