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Rational design of environmentally responsive antibodies with pH-sensing synthetic amino acids

21 Aug 2024

Abstract excerpt

Antibodies are widely used as therapeutic agents to tackle various diseases. In the present study, to enhance their clinical values, we rationally designed pH-responsivity by exploiting the idiosyncratic protonation/deprotonation profiles of non-natural amino acids. 3-Nitro- l -tyrosine, 3-cyano- l -tyrosine, and 3, 5-halogenated- l -tyrosine, each with near neutral pK a , were thus incorporated into Fab...

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PMID: 39169153
DOI: 10.1038/s41598-024-70271-3

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