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“Biophysical and Colloidal Properties Govern Anti-Drug Antibody Generation: A Case Study Using the Tumoricidal mAb 4713”

2025-09-06

Abstract excerpt

Anti-drug antibodies (ADA) are a well-recognized clinical problem, but their sporadic occurrence has limited detailed biophysical characterization of causative factors. We investigated how different stress conditions influence aggregation of a murine monoclonal antibody, mAb 4713, and the resulting potential to induce ADA in mice. Dynamic light scattering (DLS) revealed that stirring, freeze–thaw, and heat stress...

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Literature Corpus work
0f5796c2-5e25-5297-aae9-67136d14ceeb
DOI
10.1101/2025.09.03.674127
Open publication

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“Biophysical and Colloidal Properties Govern Anti-Drug Antibody Generation: A Case Study Using the Tumoricidal mAb 4713”DOI 10.1101/2025.09.03.674127
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