PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder.

doi:10.1017/S1461145710000854

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Article

PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder.

The international journal of neuropsychopharmacology - 1 Mar 2011

Schuhmacher Anna, Mössner Rainald, Höfels Susanne, Pfeiffer Ute, Guttenthaler Vera, Wagner Michael, Schwab Sibylle G, Maier Wolfgang, Zobel Astrid

Abstract excerpt

Variant rs2522833 of the Piccolo-encoding gene PCLO has recently been found to be associated with major depressive disorder (MDD). PCLO encodes a presynaptic cytomatrix protein which influences monoamine neurotransmitter release. Piccolo could therefore play an important role in treatment respons...

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Identifiers

PMID: 20701824
DOI: 10.1017/S1461145710000854

Genes

PCLO
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-20701824-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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