PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder.

doi:10.1017/S1461145710000854

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Article

PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder.

The international journal of neuropsychopharmacology - 1 Mar 2011

Schuhmacher Anna, Mössner Rainald, Höfels Susanne, Pfeiffer Ute, Guttenthaler Vera, Wagner Michael, Schwab Sibylle G, Maier Wolfgang, Zobel Astrid

Abstract excerpt

Variant rs2522833 of the Piccolo-encoding gene PCLO has recently been found to be associated with major depressive disorder (MDD). PCLO encodes a presynaptic cytomatrix protein which influences monoamine neurotransmitter release. Piccolo could therefore play an important role in treatment response to antidepressant therapy and the improvement of alterations in HPA system reactivity. We investigated the influence...

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Identifiers

PMID: 20701824
DOI: 10.1017/S1461145710000854

Genes

PCLO
CRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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