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Article

Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2) polymorphism.

Human brain mapping - 1 Mar 2017

Han Kyu-Man, Won Eunsoo, Kang June, Kim Aram, Yoon Ho-Kyoung, Chang Hun Soo, Son Kyu Ri, Lee Min-Soo, Tae Woo-Suk, Ham Byung-Joo

Abstract excerpt

The tryptophan hydroxylase-2 (TPH2) gene is considered a promising genetic candidate regarding its association with a predisposition to major depressive disorder (MDD). Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. They aimed to investigate the alterations in the cortical gyrification of the...

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Source

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Identifiers

PMID: 27807918
DOI: 10.1002/hbm.23455
PMCID: PMC6866875

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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