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Article

Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms.

Psychological medicine - 1 Dec 2007

Taylor Warren D, Macfall James R, Payne Martha E, McQuoid Douglas R, Steffens David C, Provenzale James M, Krishnan K Ranga R

Abstract excerpt

BACKGROUND: Orbitofrontal cortex (OFC) volumetric differences have been reported in depression, but in relatively small samples. Factors associated with these differences are not well described. We examined OFC volumes in a large sample of elderly depressed and non-depressed subjects, exploring the relationship between OFC volume, 5HTTLPR genotype, apolipoprotein E (APOE) genotype and hyperintense lesion volume....

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Source

Identifiers

PMID: 17335636
DOI: 10.1017/S0033291707000128

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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