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Article

Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder.

Scientific reports - 15 Feb 2017

Han Kyu-Man, Won Eunsoo, Sim Youngbo, Kang June, Han Changsu, Kim Yong-Ku, Kim Seung-Hyun, Joe Sook-Haeng, Lee Min-Soo, Tae Woo-Suk, Ham Byung-Joo

Abstract excerpt

A single nucleotide polymorphism of rs1360780 in the FKBP5 gene is associated with a predisposition to developing major depressive disorder (MDD). We investigated the interactive effects of FKBP5 rs1360780 allelic variants, DNA methylation, and the diagnosis of MDD on structural changes of the entire brain. One hundred and fourteen patients with MDD and eighty-eight healthy controls underwent T1-weighted...

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Source

Open in PubMed Open full text

Identifiers

PMID: 28198448
DOI: 10.1038/srep42621
PMCID: PMC5309810

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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