Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype.

Laboratory investigation; a journal of technical methods and pathology - 1 Sept 2017

Fujino Naoya, Kubo Hiroshi, Maciewicz Rose A

Abstract excerpt

Loss of epithelial barrier integrity is implicated in a number of human lung diseases. However, the molecular pathways underlying this process are poorly understood. In a phenotypic screen, we identified Axl kinase as a negative regulator of epithelial phenotype and function. Furthermore, suppression of Axl activity by a small molecule kinase inhibitor or downregulation of Axl expression by small interfering RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alveolar Epithelial Cells
Share to Axl Receptor Tyrosine Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Lung Diseases

Share to Multipotent Stem Cells

Share to Phosphorylation

Share to Proto-Oncogene Proteins

Share to Receptor Protein-Tyrosine Kinases

Source

Identifiers

PMID: 28553934
DOI: 10.1038/labinvest.2017.52

Genes

HOXA5
SNAI2
TBX2
TBX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype.PMID 28553934Read ↗

Targeting the AXL Receptor in Combating Smoking-related Pulmonary Fibrosis.Semantic proximity Read ↗

FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinomaSemantic proximity Read ↗

Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell MigrationSemantic proximity Read ↗

PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.Semantic proximity Read ↗

Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.Semantic proximity Read ↗

Keratinocyte migration in the developing eyelid requires LIMK2.Semantic proximity Read ↗

Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial CellsSemantic proximity Read ↗

LKB1 Controls Human Bronchial Epithelial Morphogenesis through p114RhoGEF-Dependent RhoA ActivationSemantic proximity Read ↗

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma.Semantic proximity Read ↗

Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.Semantic proximity Read ↗

Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells.Semantic proximity Read ↗

Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.