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Article

Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells.

Scientific reports - 1 Apr 2016

Ke Hengning, Masoumi Katarzyna Chmielarska, Ahlqvist Kristofer, Seckl Michael J, Rydell-Törmänen Kristina, Massoumi Ramin

Abstract excerpt

The canonical Wnt signaling can be silenced either through β-catenin-mediated ubiquitination and degradation or through phosphorylation of Tcf and Lef by nemo-like kinase (NLK). In the present study, we generated NLK deficient animals and found that these mice become cyanotic shortly before death because of lung maturation defects. NLK-/- lungs exhibited smaller and compressed alveoli and the mesenchyme remained...

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Share to Alveolar Epithelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27035511
DOI: 10.1038/srep23987
PMCID: PMC4817507

Genes

NLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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