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Article

PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.

Cancer research - 1 Apr 2015

Bonastre Ester, Verdura Sara, Zondervan Ilse, Facchinetti Federica, Lantuejoul Sylvie, Chiara Maria Dolores, Rodrigo Juan Pablo, Carretero Julian, Condom Enric, Vidal Agustin, Sidransky David, Villanueva Alberto, Roz Luca, Brambilla Elisabeth, Savola Suvi, Sanchez-Cespedes Montse

Abstract excerpt

Correct apicobasal polarization and intercellular adhesions are essential for the appropriate development of normal epithelia. Here, we investigated the contribution of the cell polarity regulator PARD3 to the development of lung squamous cell carcinomas (LSCC). Tumor-specific PARD3 alterations were found in 8% of LSCCs examined, placing PARD3 among the most common tumor suppressor genes in this malignancy. Most...

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Source

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Identifiers

PMID: 25833829
DOI: 10.1158/0008-5472.CAN-14-2444
PMCID: PMC4612637

Genes

PARD3
STAT3
RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.PMID 25833829Read ↗

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