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Article

Targeting the AXL Receptor in Combating Smoking-related Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology - 1 Jun 2021

Yang David C, Gu Shenwen, Li Ji-Min, Hsu Ssu-Wei, Chen Szu-Jung, Chang Wen-Hsin, Chen Ching-Hsien

Abstract excerpt

Tobacco smoking is a well-known risk factor for both fibrogenesis and fibrotic progression; however, the mechanisms behind these processes remain enigmatic. RTKs (receptor tyrosine kinases) have recently been reported to drive profibrotic phenotypes in fibroblasts during pulmonary fibrosis (PF). Using a phospho-RTK array screen, we identified the RTK AXL as a top upregulated RTK in response to smoke. Both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33730527
DOI: 10.1165/rcmb.2020-0303OC
PMCID: PMC8456879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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