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Article

Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.

Developmental biology - 1 Oct 2009

Li Changgong, Li Aimin, Li Min, Xing Yiming, Chen Hongyan, Hu Lingyan, Tiozzo Caterina, Anderson Stewart, Taketo Makoto Mark, Minoo Parviz

Abstract excerpt

The precise mechanisms by which beta-catenin controls morphogenesis and cell differentiation remain largely unknown. Using embryonic lung development as a model, we deleted exon 3 of beta-catenin via Nkx2.1-cre in the Catnb[+/lox(ex3)] mice and studied its impact on epithelial morphogenesis. Robust selective accumulation of truncated, stabilized beta-catenin was found in Nkx2.1-cre;Catnb[+/lox(ex3)] lungs that...

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Source

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Identifiers

PMID: 19631635
DOI: 10.1016/j.ydbio.2009.07.021
PMCID: PMC2754730

Genes

UCHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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