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Article

Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia.

Cancer research - 1 Nov 2006

Tian Jianmin, Mahmood Radma, Hnasko Robert, Locker Joseph

Abstract excerpt

Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon was replaced by a LacZ marker gene joined to the intact 5'-untranslated region. Marker expression...

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Identifiers

PMID: 17079460
DOI: 10.1158/0008-5472.CAN-06-1564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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