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Article

Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.

Cancer research - 15 Mar 2013

Briones-Orta Marco A, Levy Laurence, Madsen Chris D, Das Debipriya, Erker Yigit, Sahai Erik, Hill Caroline S

Abstract excerpt

TGF-β can act as a tumor suppressor at early stages of cancer progression and as a tumor promoter at later stages. The E3 ubiquitin ligase Arkadia (RNF111) is a critical component of the TGF-β signaling pathway, being required for a subset of responses, those mediated by Smad3-Smad4 complexes. It acts by mediating ligand-induced degradation of Ski and SnoN (SKIL), which are 2 potent transcriptional repressors....

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Source

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Identifiers

PMID: 23467611
DOI: 10.1158/0008-5472.CAN-12-1916
PMCID: PMC3672972

Genes

SKIL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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