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Article

CHEK2 gene alterations independently increase the risk of death from breast cancer in Bulgarian patients.

Neoplasma - 1 Jan 2012

Angelova S G, Krasteva M E, Gospodinova Z I, Georgieva E I

Abstract excerpt

Checkpoint kinase 2 (CHEK2) is a DNA damage-activated protein kinase implicated in cell cycle checkpoint control. The significance of CHEK2 alterations for breast cancer incidence and clinical behavior is not clear. In this study we determined the mutational spectrum and the level of promoter hyp...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22862163
DOI: 10.4149/neo_2012_079

Genes

CHEK2
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22862163-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHEK2 gene alterations independently increase the risk of death from breast cancer in Bulgarian patients.PMID 22862163Read ↗

Current perspectives on CHEK2 mutations in breast cancerSemantic proximity Read ↗

Missense mutations (p.H371Y, p.D438Y) in gene CHEK2 are associated with breast cancer risk in women of Balochistan origin.Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American populationSemantic proximity Read ↗

Identification of CHEK2 Germline Mutations in BRCA1/2- and PALB2-Negative Breast and Ovarian Cancer Patients.Semantic proximity Read ↗

Prognostic Significance of CHEK2 Mutation in Progression of Breast CancerSemantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Predisposition of an Intronic Duplication in CHEK2 Gene in the Cases of Breast Cancer from Balochistan.Semantic proximity Read ↗

Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified dentified in Breast Cancer Patients from Balochistan.Semantic proximity Read ↗

Clinicopathologic and genetic analysis of invasive breast carcinomas in women with germline CHEK2 variants.Semantic proximity Read ↗

Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.Semantic proximity Read ↗

Mutational and Expressional Deregulation of the CHEK1 Gene in Breast Cancer Patients.Semantic proximity Read ↗

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