Article
Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines.
Breast cancer research and treatment - 1 Jan 2009
Wasielewski Marijke, Hanifi-Moghaddam Pejman, Hollestelle Antoinette, Merajver Sofia D, van den Ouweland Ans, Klijn Jan G M, Ethier Stephen P, Schutte Mieke
Abstract excerpt
The CHEK2 protein plays a major role in the regulation of DNA damage response pathways. Mutations in the CHEK2 gene, in particular 1100delC, have been associated with increased cancer risks, but the precise function of CHEK2 mutations in carcinogenesis is not known. Human cancer cell lines with CHEK2 mutations are therefore of main interest. Here, we have sequenced 38 breast cancer cell lines for mutations in the...
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