Article
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.
Nature genetics - 1 May 2002
Meijers-Heijboer Hanne, van den Ouweland Ans, Klijn Jan, Wasielewski Marijke, de Snoo Anja, Oldenburg Rogier, Hollestelle Antoinette, Houben Mark, Crepin Ellen, van Veghel-Plandsoen Monique, Elstrodt Fons, van Duijn Cornelia, Bartels Carina, Meijers Carel, Schutte Mieke, McGuffog Lesley, Thompson Deborah, Easton Douglas, Sodha Nayanta, Seal Sheila, Barfoot Rita, Mangion Jon, Chang-Claude Jenny, Eccles Diana, Eeles Rosalind, Evans D Gareth, Houlston Richard, Murday Victoria, Narod Steven, Peretz Tamara, Peto Julian, Phelan Catherine, Zhang Hong Xiang, Szabo Csilla, Devilee Peter, Goldgar David, Futreal P Andrew, Nathanson Katherine L, Weber Barbara, Rahman Nazneen, Stratton Michael R
Abstract excerpt
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account for only a small fraction of breast cancer susceptibility. To find additional genes conferring susceptibility to breast cancer, we analyzed CHEK2 (also known as CHK2), which encodes a cell-cycle checkpoint kinase that is implicated in DNA repair processes involving BRCA1 and p53 (refs 3,4,5). We show that CHEK2(*)1100delC, a...
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