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Article

The CHEK2 I157T variant and breast cancer susceptibility: a systematic review and meta-analysis.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Liu Chuan, Wang Ying, Wang Qing-Shui, Wang Ya-Jie

Abstract excerpt

BACKGROUND: The cell cycle checkpoint kinase 2 (CHEK2) gene I157T variant may be associated with an increased risk of breast cancer, but it is unclear whether the evidence is sufficient to recommend testing for the mutation in clinical practice. MATERIALS AND METHODS: We systematically searched PubMed, Embase, Elsevier and Springer for relevant articles published before Nov 2011. Summary odds ratio (OR) and 95%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22799331
DOI: 10.7314/apjcp.2012.13.4.1355

Genes

CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CHEK2 I157T variant and breast cancer susceptibility: a systematic review and meta-analysis.PMID 22799331Read ↗

The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.Semantic proximity Read ↗

Patient survival and tumor characteristics associated with CHEK2:p.I157T – findings from the Breast Cancer Association ConsortiumSemantic proximity Read ↗

Current perspectives on CHEK2 mutations in breast cancerSemantic proximity Read ↗

A Comparison between CHEK2*1100delC/I157T Mutation Carrier and Noncarrier Breast Cancer Patients: A Clinicopathological Analysis.Semantic proximity Read ↗

CHEK2 variant I157T may be associated with increased breast cancer risk.Semantic proximity Read ↗

Association of two mutations in the CHEK2 gene with breast cancer.Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations.Semantic proximity Read ↗

Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

CHEK2 I157T and endometrial cancer.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

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