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A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.

The Journal of biological chemistry - 7 Jul 2017

Tetley George J N, Mott Helen R, Cooley R Neil, Owen Darerca

Abstract excerpt

Cdc42 is a Rho-family small G protein that has been widely studied for its role in controlling the actin cytoskeleton and plays a part in several potentially oncogenic signaling networks. Similar to most other small G proteins, Cdc42 binds to many downstream effector proteins to elicit its cellular effects. These effector proteins all engage the same face of Cdc42, the conformation of which is governed by the...

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Binding Sites
cdc42 GTP-Binding Protein
Mutation
Protein Binding
Protein Structure, Quaternary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

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PMID: 28539360
DOI: 10.1074/jbc.M117.789883
PMCID: PMC5500802

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