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Article

Molecular dynamics simulations reveal the activation mechanism of mutations G12V and Q61L of Cdc42.

Proteins - 1 Jul 2022

Chen Shiyao, Shu Liang, Zhao Rong, Zhao Yaxue

Abstract excerpt

Cell division control protein 42 homolog (Cdc42), which contributes to multiple cellular processes including cell proliferation and migration, is a potential target for cancer therapy, especially in the intervention of tumor migration. Cdc42's mutants G12V and Q61L are discovered constitutively active, and the overexpression of them exhibits oncogenic activities. Here, using molecular dynamics (MD) simulations...

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PMID: 35152498
DOI: 10.1002/prot.26320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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