Article
Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.
The Journal of biological chemistry - 9 Mar 2018
Ozdemir E Sila, Jang Hyunbum, Gursoy Attila, Keskin Ozlem, Li Zhigang, Sacks David B, Nussinov Ruth
Abstract excerpt
IQ motif-containing GTPase-activating proteins (IQGAPs) are scaffolding proteins playing central roles in cell-cell adhesion, polarity, and motility. The Rho GTPases Cdc42 and Rac1, in their GTP-bound active forms, interact with all three human IQGAPs. The IQGAP-Cdc42 interaction promotes metastasis by enhancing actin polymerization. However, despite their high sequence identity, Cdc42 and Rac1 differ in their...
Topics
- Allosteric Regulation
- Apoproteins
- Binding Sites
- Crystallography, X-Ray
- Dimerization
- Humans
- Models, Molecular
- Molecular Dynamics Simulation
- Mutagenesis, Site-Directed
- Mutation