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Article

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.

Nature - 9 Mar 2000

Kim A S, Kakalis L T, Abdul-Manan N, Liu G A, Rosen M K

Abstract excerpt

The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members. Activation relieves an autoinhibitory contact between the GTPase-binding domain and the carboxy-terminal region of WASP proteins. Here we report the autoinhibited structure of the GTPase-binding domain of WASP, which can be induced by the C-terminal region or by organic...

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Source

Identifiers

PMID: 10724160
DOI: 10.1038/35004513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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