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Article

An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.

Molecular cell - 28 Oct 2005

Hemsath Lars, Dvorsky Radovan, Fiegen Dennis, Carlier Marie-France, Ahmadian Mohammad Reza

Abstract excerpt

The specific and rapid formation of protein complexes is essential for diverse cellular processes such as remodeling of actin filaments in response to the interaction between Rho GTPases and the Wiskott-Aldrich syndrome proteins (WASp and N-WASp). Although Cdc42, TC10, and other members of the Rho family have been implicated in binding to and activating the WAS proteins, the exact nature of such a protein-protein...

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cdc42 GTP-Binding Protein
Protein Conformation
Protein Structure, Tertiary
rho GTP-Binding Proteins
Sequence Alignment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Static Electricity

Wiskott-Aldrich Syndrome Protein

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PMID: 16246732
DOI: 10.1016/j.molcel.2005.08.036

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