Molecular and functional consequences of the Cdc42 C81Y mutation in immune-associated malignancy.

Abstract excerpt

Cell division control protein 42 homolog (Cdc42) is a small Rho GTPase that cycles between active GTP-bound and inactive GDP-bound states to regulate cytoskeletal dynamics and immune signalling. Pathogenic variants of Cdc42 have been linked to rare immunological disorders, including a recently described C81Y mutation associated with primary immunodeficiency (PID) and Hodgkin lymphoma. Although C81Y shares...

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