Article
A Cdc42 mutant specifically activated by intersectin.
Biochemistry - 11 Oct 2005
Smith William J, Hamel Brant, Yohe Marielle E, Sondek John, Cerione Richard A, Snyder Jason T
Abstract excerpt
The Rho family GTPase Cdc42 functions as a molecular switch and controls many fundamental cellular processes such as cytoskeletal regulation, cell polarity, and vesicular trafficking. Guanine nucleotide exchange factors of the Dbl family activate Cdc42 and other Rho GTPases by catalyzing the removal of bound GDP, allowing for GTP loading, and subsequent effector recognition ultimately leading to downstream...
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