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Article

Cross-tissue transcriptome-wide association identify novel T1D susceptibility genes and drug candidates.

Frontiers in immunology - 1 Jan 2025

Liu Yiming, Cao Yu, Jiang Yaohui

Abstract excerpt

Background: The genetic mechanisms underlying type 1 diabetes (T1D) remain incompletely understood, limiting the development of targeted therapies. Methods: We performed an integrative genetic analysis to identify T1D susceptibility genes and therapeutic targets. This included a cross-tissue transcriptome-wide association study (TWAS) to pinpoint genes with genetically predicted expression associated with T1D...

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Share to Diabetes Mellitus, Type 1
Share to Gene Expression Profiling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41646970
DOI: 10.3389/fimmu.2025.1735004
PMCID: PMC12867781

Genes

ELK4
SULT1A2
WFS1
DCLK1
MAST2
PHACTR4
ST7L

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