Article
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.
Cell stem cell - 1 Sept 2016
Zeng Hui, Guo Min, Zhou Ting, Tan Lei, Chong Chi Nok, Zhang Tuo, Dong Xue, Xiang Jenny Zhaoying, Yu Albert S, Yue Lixia, Qi Qibin, Evans Todd, Graumann Johannes, Chen Shuibing
Abstract excerpt
Genome-wide association studies (GWASs) have increased our knowledge of loci associated with a range of human diseases. However, applying such findings to elucidate pathophysiology and promote drug discovery remains challenging. Here, we created isogenic human ESCs (hESCs) with mutations in GWAS-identified susceptibility genes for type 2 diabetes. In pancreatic beta-like cells differentiated from these lines, we...
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