Article

Donor-matched iPSC model reveals context-dependent T2D genetic signals in fibro-adipogenic progenitors

2026-02-06

Abstract excerpt

<h4>Summary</h4> Fibro-adipogenic progenitors (FAPs) in skeletal muscle have been implicated in type 2 diabetes (T2D), yet their heterogeneity and context-dependent regulation remain poorly understood. Here, we establish induced pluripotent stem cell (iPSC)-derived FAPs as a model of primary FAPs by leveraging a unique resource: iPSC lines and skeletal muscle biopsies obtained from 34 individuals, a subset of 30...

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Literature Corpus work: c30ebc93-19cc-592a-9924-6ff3d7b9f511
DOI: 10.64898/2026.02.04.702388

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