Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.

doi:10.1016/j.devcel.2017.04.024

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Article

Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.

Developmental cell - 22 May 2017

Liu Huayang, Dowdle James A, Khurshid Safiya, Sullivan Nicholas J, Bertos Nicholas, Rambani Komal, Mair Markus, Daniel Piotr, Wheeler Esther, Tang Xing, Toth Kyle, Lause Michael, Harrigan Markus E, Eiring Karl, Sullivan Connor, Sullivan Matthew J, Chang Serena W, Srivastava Siddhant, Conway Joseph S, Kladney Raleigh, McElroy Joseph, Bae Sooin, Lu Yuanzhi, Tofigh Ali, Saleh Sadiq M I, Fernandez Soledad A, Parvin Jeffrey D, Coppola Vincenzo, Macrae Erin R, Majumder Sarmila, Shapiro Charles L, Yee Lisa D, Ramaswamy Bhuvaneswari, Hallett Michael, Ostrowski Michael C, Park Morag, Chamberlin Helen M, Leone Gustavo

Abstract excerpt

Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adjacent Ras pathway-sensitized epithelial cells. These candidates encode components of protein...

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Identifiers

PMID: 28535374
DOI: 10.1016/j.devcel.2017.04.024
PMCID: PMC5508591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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